Innate and adaptive anti-HIV immune responses in the female reproductive tract
نویسندگان
چکیده
منابع مشابه
Killer Cell Immunoglobulin-Like Receptors Influence the Innate and Adaptive Immune Responses
Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. Human NK cells use inhibi...
متن کاملImmune Cells in the Female Reproductive Tract
The female reproductive tract has two main functions: protection against microbial challenge and maintenance of pregnancy to term. The upper reproductive tract comprises the fallopian tubes and the uterus, including the endocervix, and the lower tract consists of the ectocervix and the vagina. Immune cells residing in the reproductive tract play contradictory roles: they maintain immunity again...
متن کاملSelective Impact of HIV Disease Progression on the Innate Immune System in the Human Female Reproductive Tract
BACKGROUND We have previously demonstrated intrinsic anti-HIV activity in cervicovaginal lavage (CVL) from HIV-infected women with high CD4 counts and not on antiretroviral therapy. However, the impact of HIV disease progression on CVL innate immune responses has not been delineated. METHODS CVL from 57 HIV-infected women not on antiretroviral therapy were collected by washing the cervicovagi...
متن کاملInnate Immune Responses in HIV-Infection
The immune system comprises complex cellular and humoral systems, which are forming an interactive network to recognize and eradicate invading pathogens. Foreign molecules present on viruses, bacteria and parasites, but not on host cells, are discriminated from self through pathogen-associated molecular patterns. Upon entry of the pathogen into the body immediate non-specific immune responses a...
متن کاملManifestations of immune tolerance in the human female reproductive tract
Like other mucosal surfaces (e.g., the gastrointestinal tract, the respiratory tract), the human female reproductive tract acts as an initial barrier to foreign antigens. In this role, the epithelial surface and subepithelial immune cells must balance protection against pathogenic insults against harmful inflammatory reactions and acceptance of particular foreign antigens. Two common examples o...
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ژورنال
عنوان ژورنال: Journal of Reproductive Immunology
سال: 2013
ISSN: 0165-0378
DOI: 10.1016/j.jri.2012.10.010